@article{ref1,
title="Psychosocial impairment following mild blast-induced traumatic brain injury in rats",
journal="Behavioural brain research",
year="2021",
author="Race, Nicholas S. and Andrews, Katharine D. and Lungwitz, Elizabeth A. and Vega Alvarez, Sasha M. and Warner, Timothy R. and Acosta, Glen and Cao, Jiayue and Lu, Kun-Han and Liu, Zhongming and Dietrich, Amy D. and Majumdar, Sreeparna and Shekhar, Anantha and Truitt, William A. and Shi, Riyi",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="Traumatic brain injury (TBI) is associated with increased risk for mental health disorders, impacting post-injury quality of life and societal reintegration. TBI is also associated with deficits in psychosocial processing, defined as the cognitive integration of social and emotional behaviors, however little is known about how these deficits manifest and their contributions to post-TBI mental health. In this pre-clinical investigation using rats, a single mild blast TBI (mbTBI) induced impairment of psychosocial processing in the absence of confounding physical polytrauma, post-injury motor deficits, affective abnormalities, or deficits in non-social behavior. Impairment severity correlated with acute upregulations of a known oxidative stress metabolite, 3-hydroxypropylmercapturic acid (3-HPMA), in urine. Resting state fMRI alterations in the acute post-injury period implicated key brain regions known to regulate psychosocial behavior, including orbitofrontal cortex (OFC), which is congruent with our previous report of elevated acrolein, a marker of neurotrauma, in this region following mbTBI. OFC of mbTBI-exposed rat demonstrated elevated mRNA expression of metabotropic glutamate receptors 1 and 5 (mGluR1/5) and injection of mGluR1/5-selective agonist in OFC of uninjured rat approximated mbTBI-induced psychosocial processing impairment, demonstrating a novel role for OFC in this psychosocial behavior. Furthermore, OFC may serve as a hotspot for TBI-induced disruption of psychosocial processing and subsequent mental health disorders.<p /> <p>Language: en</p>",
language="en",
issn="0166-4328",
doi="10.1016/j.bbr.2021.113405",
url="http://dx.doi.org/10.1016/j.bbr.2021.113405"
}