@article{ref1,
title="DNA methylation under the major depression pathway predicts pediatric quality of life four-month post-pediatric mild traumatic brain injury",
journal="Clinical epigenetics",
year="2021",
author="Duan, Kuaikuai and Mayer, Andrew R. and Shaff, Nicholas A. and Chen, Jiayu and Lin, Dongdong and Calhoun, Vince D. and Jensen, Dawn M. and Liu, Jingyu",
volume="13",
number="1",
pages="140-140",
abstract="BACKGROUND: Major depression has been recognized as the most commonly diagnosed psychiatric complication of mild traumatic brain injury (mTBI). Moreover, major depression is associated with poor outcomes following mTBI; however, the underlying biological mechanisms of this are largely unknown. Recently, genomic and epigenetic factors have been increasingly implicated in the recovery following TBI. <br><br>RESULTS: This study leveraged DNA methylation within the major depression pathway, along with demographic and behavior measures (features used in the clinical model) to predict post-concussive symptom burden and quality of life four-month post-injury in a cohort of 110 pediatric mTBI patients and 87 age-matched healthy controls. The results demonstrated that including DNA methylation markers in the major depression pathway improved the prediction accuracy for quality of life but not persistent post-concussive symptom burden. Specifically, the prediction accuracy (i.e., the correlation between the predicted value and observed value) of quality of life was improved from 0.59 (p = 1.20 × 10(-3)) (clinical model) to 0.71 (p = 3.89 × 10(-5)); the identified cytosine-phosphate-guanine sites were mainly in the open sea regions and the mapped genes were related to TBI in several molecular studies. Moreover, depression symptoms were a strong predictor (with large weights) for both post-concussive symptom burden and pediatric quality of life. <br><br>CONCLUSION: This study emphasized that both molecular and behavioral manifestations of depression symptoms played a prominent role in predicting the recovery process following pediatric mTBI, suggesting the urgent need to further study TBI-caused depression symptoms for better recovery outcome.<p /> <p>Language: en</p>",
language="en",
issn="1868-7075",
doi="10.1186/s13148-021-01128-z",
url="http://dx.doi.org/10.1186/s13148-021-01128-z"
}