@article{ref1,
title="Hippocampal resting-state functional connectivity forecasts individual PTSD symptoms: a data-driven approach",
journal="Biological psychiatry: cognitive neuroscience and neuroimaging",
year="2021",
author="Fitzgerald, Jacklynn M. and Webb, Elisabeth Kate and Weis, Carissa N. and Huggins, Ashley A. and Bennett, Ken P. and Miskovich, Tara A. and Krukowski, Jessica L. and deRoon-Cassini, Terri A. and Larson, Christine L.",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="BACKGROUND: Posttraumatic Stress Disorder (PTSD) is a debilitating disorder and there is no current accurate prediction of who develops it after trauma. Neurobiologically, individuals with chronic PTSD exhibit aberrant resting-state functional connectivity (rsFC) between the hippocampus and other brain regions (e.g., amygdala, prefrontal cortex, posterior cingulate), and these aberrations correlate with severity of illness. Prior small-scale research (n < 25) has also shown that hippocampal-rsFC measured acutely after trauma is predictive of future severity using an ROI-based approach. While a promising biomarker, to-date no study has employed a data-driven approach to test whole-brain hippocampal-FC patterns in forecasting the development of PTSD symptoms. <br><br>METHODS: Ninety-eight adults at risk of PTSD were recruited from the emergency department following traumatic injury and completed resting functional magnetic resonance imaging (rsfMRI; 8min) within 1-month; 6-months later they completed the Clinician-Administered PTSD Scale (CAPS-5) for assessment of PTSD symptom severity. Whole-brain rsFC values with bilateral hippocampi were extracted (CONN) and used in a machine learning kernel ridge regression analysis (PRoNTo); both a k-folds (k=10) and 70/30 testing vs. training split approach were used for cross-validation (1,000 iterations to bootstrap confidence intervals for significance values). <br><br>RESULTS: Acute hippocampal-rsFC significantly predicted CAPS-5 scores at 6-months (r=0.30, p=0.006; MSE=120.58, p=0.006; R(2)=0.09, p=0.025). In post-hoc analyses, hippocampal-rsFC remained significant after controlling for demographics, PTSD symptoms at baseline, and depression, anxiety, and stress severity at 6-months (B=0.59, SE=0.20, p=0.003). <br><br>CONCLUSIONS: Findings suggest functional connectivity of the hippocampus across the brain acutely after traumatic injury is associated with prospective PTSD symptom severity.<p /> <p>Language: en</p>",
language="en",
issn="2451-9030",
doi="10.1016/j.bpsc.2021.08.007",
url="http://dx.doi.org/10.1016/j.bpsc.2021.08.007"
}