@article{ref1,
title="Association and genetic expression between genes involved in HPA axis and suicide behavior: a systematic review",
journal="Genes (Basel)",
year="2021",
author="Hernández-Díaz, Yazmín and Genis-Mendoza, Alma Delia and González-Castro, Thelma Beatriz and Tovilla-Zárate, Carlos Alfonso and Juárez-Rojop, Isela Esther and López-Narváez, María Lilia and Nicolini, Humberto",
volume="12",
number="10",
pages="e1608-e1608",
abstract="BACKGROUND: Suicide behavior (SB) has been highly associated with the response to stress and the hypothalamic-pituitary-adrenal (HPA) axis. The aim of this study was to summarize the results obtained in genetic studies that analyzed the HPA axis-stress pathway and SB through a systematic review. <br><br>METHODS: We performed an online search in PubMed, EBSCO, Web of Science, Scopus, and PsycoInfo databases up to May 2021. We followed the PRISMA guidelines for systematic reviews. We included case-control and expression studies that provided data on mRNA expression and single-nucleotide polymorphisms of genes associated with SB. <br><br>RESULTS: A total of 21,926 individuals participated across 41 studies (not repeats); 34 studies provided data on single-nucleotide polymorphisms in 21,284 participants and 11 studies reported data on mRNA expression in 1034 participants. Ten genes were identified: FKBP5, CRH, CRHBP, CRHR1, CRHR2, NR3C1, NR3C2, SKA2, MC2R, and POMC. <br><br>CONCLUSIONS: Our findings suggest that key stress pathway genes are significantly associated with SB and show potential as biomarkers for SB.<p /> <p>Language: en</p>",
language="en",
issn="2073-4425",
doi="10.3390/genes12101608",
url="http://dx.doi.org/10.3390/genes12101608"
}