@article{ref1,
title="Experimental asynchrony to study self-inflicted lung injury",
journal="British journal of anaesthesia",
year="2021",
author="Cronin, John N. and Formenti, Federico",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="Patient self-inflicted lung injury may be associated with worse clinical outcomes and higher mortality. Patient-ventilator asynchrony is associated with increased ventilator days and mortality, and it has been hypothesised as one of the important mechanisms leading to patient self-inflicted lung injury. However, given the observational nature of the key studies in the field so far, the hypothesis that patient-ventilator asynchrony causes patient self-inflicted lung injury has not been supported by evidence yet. Wittenstein and colleagues present a novel approach that enables controlling patient-ventilator asynchrony in a pig model of acute lung injury, to investigate the patient-ventilator asynchrony and patient self-inflicted lung injury causality. Their results suggest that increased patient-ventilator asynchrony associated with poor clinical outcomes reported in observational trials could be a marker, rather than a cause of patient self-inflicted lung injury. These findings on their own are not sufficient to justify a greater tolerance of patient-ventilator asynchrony amongst clinicians, a change for which further experimental work and clinical evidence is needed.<p /> <p>Language: en</p>",
language="en",
issn="0007-0912",
doi="10.1016/j.bja.2021.11.020",
url="http://dx.doi.org/10.1016/j.bja.2021.11.020"
}