@article{ref1,
title="Effect of memantine on prolonging safe driving in early AD: a pilot study",
journal="Canadian geriatrics journal",
year="2021",
author="Holland, Peter J. and Tappen, Ruth M. and Newman, David O. and Freeman-Costin, Katherine C. and Fisher, Lori J.",
volume="24",
number="4",
pages="292-296",
abstract="BACKGROUND: To determine the feasibility of conducting an RCT on the potential effectiveness of memantine hydrochloride in prolonging safe driving in mild AD. <br><br>METHODS: A placebo-controlled, double blind randomized trial was conducted. Forty-three individuals ≥60 with mild AD met screening criteria and were randomized. Driving ability was measured by a standardized on-road driving test. Outcomes were driving capacity at 6 and 12 months and completion of the 12-month intervention. <br><br>RESULTS: Of 43 participants randomized, 59% of the memantine group and 52% of the placebo group completed the on-road test at 12 months (p =.66). All 13 memantine group participants maintained their driving status at 12 months, whereas only 8 of the 11 placebo group participants did (p =.040, OR = 4.45). <br><br>CONCLUSIONS: Results provide the framework for designing a rigorous multisite clinical trial of memantine effect on maintaining driving capacity in mild AD.<p /> <p>Language: en</p>",
language="en",
issn="1925-8348",
doi="10.5770/cgj.24.540",
url="http://dx.doi.org/10.5770/cgj.24.540"
}