@article{ref1,
title="A successful experience using labetalol and hemodialysis to treat near-fatal caffeine poisoning: a case report with toxicodynamics",
journal="American journal of emergency medicine",
year="2021",
author="Ou, Hao-Cho and Deng, Jou-Fang and Yang, Chen-Chang and Lin, Chin-Sheng and Mao, Yan-Chiao and Tsai, Shih-Hung and Ho, Cheng-Hsuan",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="Caffeine poisoning is relatively rare, and a near-fatal caffeine overdose is highly uncommon. We present an 18-year-old male who attempted suicide with 295 mg/kg pure caffeine powder (lethal oral dose: 150-200 mg/kg) and was successfully rescued. He presented with seizures, refractory supraventricular tachycardia and hypertension for 6 h with no response to medications and cardioversion. Even with the high level of caffeine, labetalol, which is seldom administered as a treatment for caffeine poisoning-induced tachycardia, successfully relieved refractory tachycardia. Then, hemodialysis ultimately eliminated serum caffeine and completely alleviated caffeine-related central nervous system toxicity. We discuss the clinical symptoms, management and toxicodynamics based on the concentration of caffeine and its metabolites in serum and urine.<p /> <p>Language: en</p>",
language="en",
issn="0735-6757",
doi="10.1016/j.ajem.2021.11.049",
url="http://dx.doi.org/10.1016/j.ajem.2021.11.049"
}