@article{ref1,
title="Association of childhood maltreatment history with salivary interleukin-6 diurnal patterns and C-reactive protein in healthy adults",
journal="Brain, behavior, and immunity",
year="2022",
author="Hori, Hiroaki and Izawa, Shuhei and Yoshida, Fuyuko and Kunugi, Hiroshi and Kim, Yoshiharu and Mizukami, Shinya and Inoue, Yusuke and Tagaya, Hirokuni and Hakamata, Yuko",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="Childhood maltreatment has been associated with increased inflammation, as indicated by elevated levels of proinflammatory markers such as interleukin-6 (IL-6) and C-reactive protein (CRP). Studies in humans show that secretion of IL-6 follows a clear circadian rhythm, implying that its disturbed rhythm represents an important aspect of dysregulated inflammatory system. However, possible alterations in diurnal secretion patterns of IL-6 associated with childhood maltreatment have not been studied. Here we investigated this association in 116 healthy adults. Diurnal levels of IL-6 were examined using saliva samples collected at 5 times a day across 2 consecutive days. Salivary CRP levels were also determined by averaging measurements at 2 times a day for 2 days. Different types of childhood maltreatment were assessed with the Childhood Trauma Questionnaire (CTQ). CTQ total and emotional abuse scores were significantly correlated with smaller IL-6 diurnal variation as indexed by lower standard deviation across the measurement times (p=0.024 and p=0.008, respectively). Individuals with emotional abuse, as defined by a cut-off score of CTQ, showed flatter IL-6 rhythm than those without (p=0.031). These results, both correlation and group comparison, remained significant after controlling for age, sex, and body mass index. Childhood maltreatment was not associated with total outputs of IL-6 or CRP. Our findings indicate that childhood trauma can have a long-term negative effect on the circadian rhythm of inflammatory system. The findings are consistent with those of previous studies on adulthood trauma, suggesting that the disrupted IL-6 rhythmicity may be associated with a broad range of trauma-related conditions.<p /> <p>Language: en</p>",
language="en",
issn="0889-1591",
doi="10.1016/j.bbi.2022.01.020",
url="http://dx.doi.org/10.1016/j.bbi.2022.01.020"
}