@article{ref1,
title="Traumatic brain injury and dementia risk in male veteran older twins-controlling for genetic and early life non-genetic factors",
journal="Alzheimer's and dementia",
year="2022",
author="Plassman, Brenda L. and Chanti-Ketterl, Marianne and Pieper, Carl F. and Yaffe, Kristine",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="INTRODUCTION: This study leveraged the twin study design, which controls for shared genetic and early life exposures, to investigate the association between traumatic brain injury (TBI) and dementia. <br><br>METHODS: Members of the National Academy of Sciences-National Research Council's Twins Registry of World War II male veterans were assigned a cognitive outcome based on a multi-step assessment protocol. History of TBI was obtained via interviews. <br><br>RESULTS: Among 8302 individuals, risk of non-Alzheimer's disease (non-AD) dementia was higher in those with TBI (hazard ratio [HR] = 2.00, 95% confidence interval [CI], 0.97-4.12), than for AD (HR = 1.23, 95% CI, 0.76-2.00). To add more control of genetic and shared environmental factors, we analyzed 100 twin pairs discordant for both TBI and dementia onset, and found TBI-associated risk for non-AD dementia increased further (McNemar odds ratio = 2.70; 95% CI, 1.27-6.25). <br><br>DISCUSSION: These findings suggest that non-AD mechanisms may underlie the association between TBI and dementia, potentially providing insight into inconsistent results from prior studies.<p /> <p>Language: en</p>",
language="en",
issn="1552-5260",
doi="10.1002/alz.12571",
url="http://dx.doi.org/10.1002/alz.12571"
}