@article{ref1,
title="Low-dose clozapine monotherapy for recurrent non-suicidal self-injury: a case report",
journal="Asian journal of psychiatry",
year="2022",
author="Yang, Jae-Won and Jung, Sung-Won and Lee, Hojun",
volume="73",
number="",
pages="e103113-e103113",
abstract="Non-suicidal self-injury (NSSI) is a challenging issue in clinical settings. In the present case series, we report two female adolescents with recurrent depression and NSSI. Numerous approaches, such as anti-depressants, anti-psychotics, and even electroconvulsive therapy, were not effective. Clozapine has been implemented in a broad spectrum of psychiatric disorders, particularly refractory depression, impulse control problems, suicidal ideation, and NSSI. With a low dose (12.5-25 mg) of clozapine, the depressive symptoms and NSSI remarkably improved, and the improvement was sustained over four months after discharge. Low-dose clozapine monotherapy may be a treatment option with refractory depression and NSSI.<p /> <p>Language: en</p>",
language="en",
issn="1876-2018",
doi="10.1016/j.ajp.2022.103113",
url="http://dx.doi.org/10.1016/j.ajp.2022.103113"
}