@article{ref1,
title="Interaction effect between childhood abuse and interleukin-1β levels on suicidality in depressed patients",
journal="European archives of psychiatry and clinical neuroscience",
year="2022",
author="Lee, Ju-Yeon and Jhon, Min and Kim, Ju-Wan and Kang, Hee-Ju and Kim, Sung-Wan and Shin, Il-Seon and Cho, Hwa Jin and Chun, Byeong Jo and Kim, Jae-Min",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="INTRODUCTION: The roles of childhood abuse and interleukin (IL)-1β levels, a representative pro-inflammatory cytokine, in suicidal behavior are unclear. This study investigated the main and interactive effects of childhood abuse and IL-1β levels on suicidal behavior in patients with a depressive disorder before and after pharmacological treatment. <br><br>METHODS: At baseline, exposure to self-reported childhood abuse, including emotional, physical, and sexual abuse, before the age of 16 years, and IL-1β levels, were measured in 1,094 outpatients with a depressive disorder, 884 of whom were followed for 1 year. Suicidal behavior was evaluated, including previous suicide attempts (at baseline), suicidal ideation (at baseline and follow-up), and fatal/non-fatal suicide attempts (at follow-up). The main and interaction effects of self-reported childhood abuse and IL-1β level on the four types of suicidal behavior were analyzed using logistic regression after adjusting for covariates. <br><br>RESULTS: Individual associations of self-reported childhood abuse were significant only with previous suicidal attempt but not with other suicidal behaviors. There was no significant association of plasma IL-1β level with any suicidal behavior. There were significant interactive associations of self-reported childhood abuse and a high IL-1β level on previous suicide attempts, baseline suicidal ideation, and fatal/non-fatal suicidal attempts during follow-up. <br><br>CONCLUSION: Suicidal behavior in patients with a depressive disorder could be influenced by considering the interactive effect of childhood abuse and IL-1β levels. Our study suggests that childhood trauma and biochemical factors play roles in the pathology of suicide in depressed patients.<p /> <p>Language: en</p>",
language="en",
issn="0940-1334",
doi="10.1007/s00406-022-01408-6",
url="http://dx.doi.org/10.1007/s00406-022-01408-6"
}