@article{ref1,
title="The "Talk and Die" phenomenon in traumatic brain injury: a meta-analysis",
journal="Clinical neurology and neurosurgery",
year="2022",
author="Al-Salihi, Mohammed Maan and Ayyad, Ali and Al-Jebur, Maryam Sabah and Rahman, Md Moshiur",
volume="218",
number="",
pages="e107262-e107262",
abstract="INTRODUCTION: Risk factors for &quot;Talk and Die&quot; phenomenon following Traumatic Brain Injury (TBI) are poorly identified in literature, and studies attempting to identify those factors yielded conflicting results. <br><br>AIM: To provide level 1 evidence on the significance of potential risk factors predictive of &quot;Talk and Die&quot; phenomenon following TBI. <br><br>METHODOLOGY: A systematic review and meta-analysis were performed. A fixed effect model for age, admission Glasgow Coma Scale (GCS), Abbreviated Injury Scale (AIS), and Injury Severity Score (ISS) parameters were performed. <br><br>RESULTS: Of 35,582 patients analyzed, 2397 patients experienced the &quot;Talk and Die&quot; phenomenon. Absence of intracranial hematoma (OR=0.137, CI: 0.276-0.991, =0.047), Older age (Hedge's g=0.153, CI: 0.104-0.202, p < 0.001), lower GCS score (Hedge's g=-0.111, CI: 0.062-0.160, p < 0.001), lucid interval duration of ≥ 24 h (OR=4.176, CI: 2.806-6.215, p = 0.000), higher AIS scores (Hedge's g was 0.138, CI: 0.089-0.188, p < 0.001), and lower ISS scores (Hedge's g=0.137, CI: 0.088-0.186, p < 0.001) were identified as risk factors for mortality. <br><br>CONCLUSION: Considering our results and others, we conclude that absence or presence of intracranial hematomas, older age, lower GCS, lucid interval ≥ 24 h, High AIS, and low or high ISS predispose to a &quot;Talk and Die&quot; phenomenon following a Traumatic Brain Injury.<p /> <p>Language: en</p>",
language="en",
issn="0303-8467",
doi="10.1016/j.clineuro.2022.107262",
url="http://dx.doi.org/10.1016/j.clineuro.2022.107262"
}