@article{ref1,
title="Intimate partner violence and oral HIV pre-exposure prophylaxis adherence among young African women",
journal="AIDS",
year="2022",
author="Delanymoretlwe, Sinead and Celum, Connie and Pence, Brian W. and Hightow-Weidman, Lisa and Powers, Kimberly A. and Pettifor, Audrey and Giovenco, Danielle and Hosek, Sybil and Donnell, Deborah and Anderson, Peter L. and Mgodi, Nyaradzo and Bekker, Linda-Gail",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="OBJECTIVE: To estimate the effect of intimate partner violence (IPV) on oral PrEP adherence among adolescent girls and young women (AGYW). <br><br>DESIGN: We conducted a secondary analysis of data from HIV Prevention Trials Network 082 (HPTN 082), a multisite prospective study designed to assess oral PrEP adherence among AGYW in southern Africa. <br><br>METHODS: We estimated the relative prevalence of high PrEP adherence 3 and 6 months after initiation among AGYW 16-25 years who reported a history of any IPV in the past year at enrollment versus AGYW who did not, both overall and by age. High adherence was defined as an intracellular tenofovir-diphosphate concentration at least 700 fmol/punch in dried blood spots. <br><br>RESULTS: Among 409 PrEP-initiating AGYW, half (49%) reported experiencing any IPV by a current/recent partner in the year prior to enrollment. Overall, a similar proportion of AGYW who reported IPV had high PrEP adherence at months 3 and 6 as AGYW who did not report IPV. There was, however, evidence of effect modification by age at month 3: among AGYW less than 21 years, those who reported IPV were less than half as likely to have high adherence [adjusted PR (aPR) = 0.43, 95% confidence interval (CI) 0.22-0.86]; among AGYW aged 21 years, those who reported IPV were more than twice as likely to have high adherence (aPR = 2.21, 95% CI 1.34-3.66). At month 6, effect estimates within each age stratum were consistent in direction to those at month 3. <br><br>CONCLUSION: IPV events may either impede or motivate PrEP adherence among African AGYW, with age appearing to be an important consideration for IPV-related adherence interventions.<p /> <p>Language: en</p>",
language="en",
issn="0269-9370",
doi="10.1097/QAD.0000000000003216",
url="http://dx.doi.org/10.1097/QAD.0000000000003216"
}