@article{ref1,
title="Neurocognition and its association with adverse childhood experiences and familial risk of mental illness",
journal="Progress in neuro-psychopharmacology and biological psychiatry",
year="2022",
author="Lakkireddy, Sai Priya and Balachander, Srinivas and Dayalamurthy, Pavithra and Bhattacharya, Mahashweta and Joseph, Mino Susan and Kumar, Pramod and Kannampuzha, Anand Jose and Mallappagari, Sreenivasulu and Narayana, Shruthi and Alexander, Alen Chandy and Moorthy, Muthukumaran and Sheth, Sweta and Puzhakkal, Joan C. and Ramesh, Vinutha and Thatikonda, Navya Spurthi and Selvaraj, Sowmya and Ithal, Dhruva and Sreeraj, Vanteemar S. and Mahadevan, Jayant and Holla, Bharath and Venkatasubramanian, Ganesan and John, John P. and Murthy, Pratima and Benegal, Vivek and Reddy, Y. C. Janardhan and Jain, Sanjeev and Viswanath, Biju",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="Environmental factors such as adverse childhood experiences (ACEs) may affect neurocognition, an endophenotype for several mental illnesses. This study examines the effect of ACEs on neurocognitive performance in first-degree relatives (FDRs) of patients with severe mental illness to determine whether familial risk has a moderating effect on the relationship between ACEs and neurocognition. Unaffected FDRs from multiplex families with severe mental illnesses (schizophrenia, bipolar disorder, obsessive-compulsive disorder, or alcohol use disorder) (n = 324) and healthy controls (with no familial risk) (n = 188) underwent neurocognitive tests for processing speed, new learning, working memory and Theory of Mind. ACEs were measured using the WHO ACE-International Questionnaire (ACE-IQ). Regression models were done to predict each neurocognitive domain by the effect of familial risk, ACE-IQ Score and their interaction (familial risk*ACE-IQ score). The main effect of familial risk predicted poor performance in all domains of neurocognition (p < 0.01), and the interaction had negative association with global neurocognition (β = -0.093, p = 0.009), processing speed (β = -0.109, p = 0.003) and working memory (β = -0.092, p = 0.01). Among the ACEs sub-domains, only maltreatment, specifically the main effect of physical neglect, and interaction effect sexual abuse with familial risk predicted poorer neurocognition. In FDRs of schizophrenia and bipolar disorder, only the main effects of familial risk were significantly associated with neurocognition. We conclude that ACEs (especially maltreatment) are associated with neurocognition, but the relationship between childhood adversity and neurocognition is moderated by familial risk of mental illness. Genetic/familial vulnerability may have a stronger association with neurocognition in schizophrenia and bipolar disorder.<p /> <p>Language: en</p>",
language="en",
issn="0278-5846",
doi="10.1016/j.pnpbp.2022.110620",
url="http://dx.doi.org/10.1016/j.pnpbp.2022.110620"
}