@article{ref1,
title="Association between early risk factors and level of functioning at age seven in children at familial risk for schizophrenia or bipolar disorder - The Danish High Risk and Resilience Study VIA 7",
journal="Scandinavian journal of child and adolescent psychiatry and psychology",
year="2021",
author="Bundgaard, Anette Faurskov and Hemager, Nicoline and Gantriis, Ditte Lou and Steffensen, Nanna Lawaetz and Burton, Birgitte Klee and Ellersgaard, Ditte and Christiani, Camilla Jerlang and Spang, Katrine S. and Carlsen, Anders Helles and Bliksted, Vibeke and Plessen, Kerstin J. and Jepsen, Jens Richardt Møllegaard and Nordentoft, Merete and Mors, Ole and Thorup, Anne A. E. and Greve, Aja Neergaard",
volume="10",
number="1",
pages="12-23",
abstract="Background: Facing multiple risk factors, relative to single risk factor exposure early in life can have great implications for negative child development.   ObjectiveWe aim to examine whether the prevalence of early risk factors is higher among children with familial high risk for schizophrenia or bipolar disorder compared to controls. Further, to investigate the association between number of early risk factors and level of functioning at age seven, and whether this possible association is different in children with familial high risk compared to controls.   Method: The Danish High Risk and Resilience Study VIA 7 is a population-based cohort study of children of parents diagnosed with schizophrenia (N = 202), bipolar disorder (N = 120) and controls (N = 200). We conducted a semi-structured anamnestic interview with the child's primary caregiver to assess early risk factors from pregnancy to age four. We used the Children's Global Assessment Scale to measure level of functioning at age seven.   Results: 13 out of 17 risk factors were more prevalent in children at familial high risk for schizophrenia and 7 out of 17 risk factors were more prevalent in children at familial high risk for bipolar disorder compared to controls. Level of functioning decreased 2.7 (95% CI, 2.2; 3.3)-points per risk factor,  but  the  association  was  not  significantly  different  across  the  three groups (p = 0.09).    Conclusions: Our  results  showed  that  children  at  age  seven  with  familial  high  risk  for  schizophrenia  or  bipolar  disorder experience a greater number of early risk factors. A higher number of early risk factors were associated with lower level of functioning at age seven. However, the association is not different for children with familial high risk or controls. <p /> <p>Language: it</p>",
language="it",
issn="2245-8875",
doi="10.2478/sjcapp-2022-0001",
url="http://dx.doi.org/10.2478/sjcapp-2022-0001"
}