@article{ref1,
title="Emotional resilience predicts preserved white matter microstructure following mild traumatic brain injury",
journal="Biological psychiatry: cognitive neuroscience and neuroimaging",
year="2022",
author="Cai, Lanya T. and Brett, Benjamin L. and Palacios, Eva M. and Yuh, Esther L. and Bourla, Ioanna and Wren-Jarvis, Jamie and Wang, Yang and Donald, Christine Mac and Diaz-Arrastia, Ramon and Giacino, Joseph T. and Okonkwo, David O. and Levin, Harvey S. and Robertson, Claudia S. and Temkin, Nancy and Markowitz, Amy J. and Manley, Geoffrey T. and Stein, Murray B. and McCrea, Michael A. and Zafonte, Ross D. and Nelson, Lindsay D. and Mukherjee, Pratik",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="BACKGROUND: Adult patients with mild traumatic brain injury (mTBI) exhibit distinct phenotypes of emotional and cognitive functioning identified by latent profile analysis of clinical neuropsychological assessments. When discerned early after injury, these latent clinical profiles have been found to improve prediction of long-term outcomes from mTBI. The present study hypothesized that white matter (WM) microstructure is better preserved in an emotionally resilient (ER) mTBI phenotype compared with a neuropsychiatrically distressed (ND) mTBI phenotype. <br><br>METHODS: The present study used diffusion MRI to investigate and compare WM microstructure in major association, projection, and commissural tracts between the two phenotypes and over time. Diffusion MR images from 172 mTBI patients were analyzed to compute individual diffusion tensor imaging (DTI) maps at 2 weeks and 6 months postinjury. <br><br>RESULTS: By comparing the DTI parameters between the two phenotypes at global, regional, and voxel levels, the present study showed that the ER patients have higher axial diffusivity (AD) compared to their ND counterparts early after mTBI. Longitudinal analysis revealed greater compromise of WM microstructure in ND patients, with greater decrease of global AD and more widespread decrease of regional AD during the first 6 months after injury compared to their ER counterparts. <br><br>CONCLUSIONS: These results provide neuroimaging evidence of WM microstructural differences underpinning mTBI phenotypes identified from neuropsychological assessments and show differing longitudinal trajectories of these biological effects. These findings suggest diffusion MRI can provide short- and long-term imaging biomarkers of resilience.<p /> <p>Language: en</p>",
language="en",
issn="2451-9030",
doi="10.1016/j.bpsc.2022.08.015",
url="http://dx.doi.org/10.1016/j.bpsc.2022.08.015"
}