@article{ref1,
title="Relationship between alcohol co-ingestion and clinical outcome in pesticide self-poisoning: a systematic review and meta-analysis",
journal="Alcohol and alcoholism",
year="2022",
author="Dhanarisi, Jeevan and Perera, Sriyani and Wijerathna, Thilini and Gawarammana, Indika and Shihana, Fathima and Pathiraja, Vindya and Eddleston, Michael and Mohamed, Fahim",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="AIM: Alcohol is a commonly co-ingested compound during self-poisoning with pesticides. Clinical experiences suggest alcohol co-ingestion (or withdrawal) makes patient management more difficult after self-poisoning and may contribute to poor clinical outcomes. We aimed to systematically review the world literature to explore the relationship between alcohol co-ingestion and outcome in pesticide self-poisoning. <br><br>METHODS: We searched 13 electronic databases and Google scholar, conducted citation searching and a review of reference lists to find studies which investigated the relationship of alcohol with clinical outcome of pesticide self-poisoning in different countries. Thirteen studies, including 11 case series/reports and two cohort studies were considered for inclusion. <br><br>RESULTS: Meta-analysis showed that alcohol co-ingestion in pesticide self-poisoning was associated with increased risk of death [odds ratio (OR) 4.9, 95% confidence interval (CI) 2.9-8.2 P<0.0001] and that alcohol co-ingested group required intubation eight times more often than non-co-ingested group in organophosphorus insecticide self-poisoning (OR 8.0, 95% CI 4.9-13.0 P<0.0001). Cases who co-ingested alcohol were older than non-alcohol group in two studies. One cohort study demonstrated that alcohol co-ingestion was associated with larger pesticide ingestions but did not itself affect the outcome. <br><br>CONCLUSIONS: This systematic review indicates that alcohol co-ingestion may worsen clinical outcome in pesticide self-poisoning.<p /> <p>Language: en</p>",
language="en",
issn="0735-0414",
doi="10.1093/alcalc/agac045",
url="http://dx.doi.org/10.1093/alcalc/agac045"
}