@article{ref1,
title="High serum levels of IL-6 are associated with suicide attempt but not with high lethality suicide attempts: a preliminary case-control study",
journal="International journal of environmental research and public health",
year="2022",
author="López-Narváez, María Lilia and Juárez-Rojop, Isela Esther and Genis-Mendoza, Alma Delia and Castillo-Avila, Rosa Giannina and Nicolini, Humberto and González-Castro, Thelma Beatriz and Tovilla-Zárate, Carlos Alfonso and Hernández-Díaz, Yazmín and Ramos-Méndez, Miguel Ángel and Nolasco-Rosales, Germán Alberto and Dionisio-García, Diana María",
volume="19",
number="22",
pages="e14735-e14735",
abstract="Suicide attempts are an emerging health problem around the world. Increased levels of IL-6 have been associated with suicidal behavior. Therefore, the aims of this study were to evaluate the serum levels of IL-6 in individuals with suicide attempts and a comparison group and to associate the IL-6 levels with the lethality of the suicide attempt. Additionally, we associated the rs2228145 polymorphism of the IL6R gene with suicide attempts or with the IL-6 serum levels. Suicide attempts and their lethality were evaluated using the Columbia Suicide Severity Rating Scale. The serum concentrations of IL-6 were measured by the ELISA technique in individuals with suicide attempts and then compared to a control group. The rs2228145 polymorphism of the IL6R gene was analyzed by real-time polymerase chain reaction. We found elevated serum levels of IL-6 in the suicide attempt group when compared to the control group (F = 10.37, p = 0.002). However, we found no differences of the IL-6 levels between high and low lethality. The IL6R gene polymorphism rs2479409 was not associated with suicide attempts. Our data suggest that IL-6 serum is increased in individuals with suicide attempts.<p /> <p>Language: en</p>",
language="en",
issn="1661-7827",
doi="10.3390/ijerph192214735",
url="http://dx.doi.org/10.3390/ijerph192214735"
}