@article{ref1,
title="Fracture rates in children with cerebral palsy: a Danish, nationwide register-based study",
journal="Clinical epidemiology",
year="2022",
author="Granild-Jensen, Jakob Bie and Pedersen, Alma Becic and Kristiansen, Eskild Bendix and Langdahl, Bente and Møller-Madsen, Bjarne and Søndergaard, Charlotte and Farholt, Stense and Vestergaard, Esben Thyssen and Rackauskaite, Gija",
volume="14",
number="",
pages="1405-1414",
abstract="BACKGROUND: In children with cerebral palsy (CP), fracture rates have been reported to be higher than in the general population but age-specific fracture rates have not been directly compared and the effect of comorbid epilepsy needs elucidation. This impairs decision-making regarding bone health interventions. <br><br>AIM: We aimed to establish the age-specific fracture rates in children with CP with and without epilepsy in Denmark. <br><br>MATERIALS AND METHODS: Data from Danish registers were combined to establish cohorts of children with and without CP born in Denmark from 1997 to 2007. Fracture rates were calculated for 1997-2016. <br><br>RESULTS: We identified 1,451 children with CP and 787,159 without CP. Female/male fracture rates per 1,000 person-years were 23/27 with CP and 23/29 without CP. Male sex, epilepsy and anti-seizure medication, but not the diagnosis of CP or GMFCS-level, were associated with higher fracture rates. Relatively more lower extremity fractures occurred in non-ambulant children with CP.   INTERPRETATION/CONCLUSION: We found no increased fracture rates in children with CP when compared to peers; however, fracture locations suggested bone fragility in non-ambulant children. All children with epilepsy and on anti-seizure medication had increased fracture rates. We suggest bone health optimization in these groups.<p /> <p>Language: en</p>",
language="en",
issn="1179-1349",
doi="10.2147/CLEP.S381343",
url="http://dx.doi.org/10.2147/CLEP.S381343"
}