@article{ref1,
title="Serotonin transporter availability in physically aggressive personality disordered patients: associations with trait and state aggression, and response to fluoxetine",
journal="Psychopharmacology",
year="2023",
author="Rosell, Daniel R. and Slifstein, Mark and Thompson, Judy and Xu, Xiaoyan and Perez-Rodriguez, M. Mercedes and McClure, Margaret M. and Hazlett, Erin A. and New, Antonia S. and Nabulsi, Nabeel and Huang, Yiyun and Carson, Richard E. and Siever, Larry S. and Abi-Dargham, Anissa and Koenigsberg, Harold W.",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="RATIONALE: Characterizing the neuroanatomical basis of serotonergic abnormalities in severe, chronic, impulsive aggression will allow for rational treatment selection, development of novel therapeutics, and biomarkers to identify at-risk individuals. <br><br>OBJECTIVES: The aim of this study is to identify associations between regional serotonin transporter (5-HTT) availability and trait and state aggression, as well as response to the anti-aggressive effects of fluoxetine. <br><br>METHODS: We examined 5-HTT availability using positron emission tomography (PET) imaging with [(11)C]DASB in personality disordered patients with current physical intermittent explosive disorder (IED; n = 18), and healthy comparison participants (HC; n = 11), in the anterior cingulate cortex (ACC), amygdala (AMY), ventral striatum (VST), and midbrain (MID). After PET imaging, IED patients were treated with fluoxetine 20 mg daily (n = 9) or placebo (n = 6) for 12 weeks. Trait and state aggression, trait callousness, and childhood trauma were assessed. <br><br>RESULTS: In IED patients, trait aggression was positively associated with [(11)C]DASB binding in the ACC and VST; covarying for trait callousness and childhood trauma enhanced these correlations. Baseline state aggression was positively correlated with ACC [(11)C]DASB in IED patients. Greater baseline VST [(11)C]DASB binding predicted greater decreases in state aggression with fluoxetine treatment. <br><br>CONCLUSIONS: Consistent with prior reports, ACC 5-HTT is related to trait aggression, and adjusting for factors related to proactive (callousness) and reactive (childhood trauma) aggression subtypes further resolves this relationship. Novel findings of the study include a better understanding of the association between regional 5-HTT availability and state aggression, and the involvement of VST 5-HTT with trait aggression, and with the anti-aggressive effects of fluoxetine.<p /> <p>Language: en</p>",
language="en",
issn="0033-3158",
doi="10.1007/s00213-022-06306-2",
url="http://dx.doi.org/10.1007/s00213-022-06306-2"
}