@article{ref1,
title="CANNabinoid Drug Interaction Review (CANN-DIR™)",
journal="Medical Cannabis and Cannabinoids",
year="2023",
author="Kocis, Paul T. and Wadrose, Samuel and Wakefield, Ryan Lee and Ahmed, Aqib and Calle, Renata and Gajjar, Rohan and Vrana, Kent E.",
volume="6",
number="",
pages="1-7",
abstract="Non-prescription cannabidiol (CBD) and medical marijuana (cannabis) currently do not have US Food and Drug Administration (FDA)-approved prescribing information nor a dedicated resource to evaluate potential cannabinoid drug-drug interactions with other medications. The CANNabinoid Drug Interaction Review (CANN-DIR™) is a free web-based platform that has been developed to screen for potential drug-drug interactions from the perspective of how a cannabinoid delta-9-tetrahydrocannabinol (THC), CBD, or a combination of THC/CBD may affect the metabolism of another prescribed medication. CANN-DIR™ is based on FDA-approved prescribing information for the prescription cannabinoids (dronabinol, nabilone, nabiximols, and prescription CBD) and other FDA-approved prescribing information for medications sharing similar metabolic enzymes (e.g., the FDA &quot;Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers&quot;). The Summary of Product Characteristics (SmPC) was the source of drug-drug interaction information for the combined ∆<sup>9</sup>-THC & CBD product nabiximols (Sativex<sup>®</sup>). CANN-DIR™ provides an expeditious review of cannabinoid drug-drug interaction information, and also a platform from which the patient and health care provider can print out the search results to either initiate a conversation, or for the health care provider to provide a written information sheet to supplement their verbal discussion. Additionally, to more effectively reach a global audience, the end user of CANN-DIR™ has the ability to currently navigate and print results in any of the following ten languages: Chinese, English, French, German, Nepali, Polish, Russian, Spanish, Swedish, and Vietnamese.<p /> <p>Language: en</p>",
language="en",
issn="2504-3889",
doi="10.1159/000528528",
url="http://dx.doi.org/10.1159/000528528"
}