@article{ref1,
title="In vivo serotonin transporter and 1A receptor binding potential and ecological momentary assessment (EMA) of stress in major depression and suicidal behavior",
journal="European Neuropsychopharmacology",
year="2023",
author="Bartlett, Elizabeth A. and Zanderigo, Francesca and Stanley, Barbara and Choo, Tse-Hwei and Galfalvy, Hanga C. and Pantazatos, Spiro P. and Sublette, M. Elizabeth and Miller, Jeffrey M. and Oquendo, Maria A. and Mann, J. John",
volume="70",
number="",
pages="1-13",
abstract="We examined relationships between the serotonin system and stress in major depression and suicidal behavior. Twenty-five medication-free depressed participants (13 suicide attempters) underwent same-day [(11)C]DASB and [(11)C]CUMI-101 positron emission tomography (PET) imaging. Binding potential (BP(ND)) to the serotonin transporter (5-HTT) and serotonin 1A (5-HT(1A)) receptor, respectively, was quantified using the NRU 5-HT atlas, reflecting distinct spatial distributions of multiple serotonin targets. Ecological momentary assessment (EMA) measured current stress over one week proximal to imaging. EMA stress did not differ between attempters and non-attempters. In all depressed participants, 5-HTT and 5-HT(1A) BP(ND) were unrelated to EMA stress. There were region-specific effects of 5-HTT (p=0.002) and 5-HT(1A) BP(ND) (p=0.03) in attempters vs. nonattempters. In attempters, region-specific associations between 5-HTT (p=0.03) and 5-HT(1A) (p=0.005) BP(ND) and EMA stress emerged. While no post-hoc 5-HTT BP(ND) correlations were significant, 5-HT(1A) BP(ND) correlated positively with EMA stress in attempters in 9/10 regions (p-values<0.007), including the entire cortex except the largely occipital region 5. Brodmann-based regional analyses found diminished effects for 5-HTT and subcortically localized positive corrrelations between 5-HT(1A) and EMA stress, in attempters only. Given comparable depression severity and childhood and current stress between attempters and nonattempters, lower 5-HTT binding in attempters vs. nonattempters may suggest a biological risk marker. Localized lower 5-HTT and widespread higher 5-HT(1A) binding with stress among attempters specifically may suggest that a serotonergic phenotype might be a key determinant of risk or resiliency for suicidal behavior.<p /> <p>Language: en</p>",
language="en",
issn="0924-977X",
doi="10.1016/j.euroneuro.2023.01.006",
url="http://dx.doi.org/10.1016/j.euroneuro.2023.01.006"
}