@article{ref1,
title="Childhood trauma and self-harm in youths with bipolar disorders",
journal="Current neuropharmacology",
year="2023",
author="Janiri, Delfina and Di Luzio, Michelangelo and Montanari, Silvia and Hirsch, Daniele and Simonetti, Alessio and Moccia, Lorenzo and Conte, Eliana and Contaldo, Ilaria and Veredice, Chiara and Mercuri, Eugenio and Sani, Gabriele",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="BACKGROUND: Bipolar disorders (BD) in youth are associated with high risk of self-harm behaviors. Childhood trauma (CT) is a relevant environmental stressor that is related with both BD diagnosis and self-harm in adulthood. It is not yet established whether CT may impact on self-harm risk in youth. Therefore, the aim of this study was to investigate the distribution patterns of CT in youth BD with and without self-harm. <br><br>METHODS: We assessed 273 participants (aged 13-25 years), 96 youths with BD according to DSM-5 criteria and 177 healthy controls (HC). History of CT was obtained using the Childhood Trauma Questionnaire (CTQ). The association between CT and self-harm was tested using multivariate statistical models. <br><br>RESULTS: Over 45% of participants with BD reported lifetime self-harm. The BD Self-harm group reported more emotional abuse, emotional neglect, sexual abuse, and physical abuse than HC. The BD No-Self-harm group reported more emotional abuse than HC. The BD Self-harm group reported more emotional abuse and neglect than the BD No-Self-harm group, The BD Self-harm group also reported more separated parents, hospitalizations, smoking, use of antiepileptics, antipsychotics and lithium. Emotional abuse was an independent predictor of self-harm in youths with BD. <br><br>CONCLUSIONS: Findings support the importance of assessing CT, in particular emotional abuse, in youth with BD at risk for self-harm.<p /> <p>Language: en</p>",
language="en",
issn="1570-159X",
doi="10.2174/1570159X21666230213155249",
url="http://dx.doi.org/10.2174/1570159X21666230213155249"
}