@article{ref1,
title="Concordance between substance use self-report and hair analysis in community-based adolescents",
journal="American journal of drug and alcohol abuse encompassing all addictive disorders",
year="2023",
author="Haist, Frank and Lisdahl, Krista M. and Huestis, Marilyn A. and Pelham, William E. 3rd and Tapert, Susan F. and Sullivan, Ryan M. and Wade, Natasha E.",
volume="49",
number="1",
pages="76-84",
abstract="BACKGROUND: Accurate drug use identification through subjective self-report and toxicological biosample (hair) analysis are necessary to determine substance use sequelae in youth. Yet consistency between self-reported substance use and robust, toxicological analysis in a large sample of youth is understudied.<br><br>OBJECTIVES: We aim to assess concordance between self-reported substance use and hair toxicological analysis in community-based adolescents.<br><br>METHODS: Hair results by LC-MS/MS and GC-MS/MS and self-reported past-year substance use from an Adolescent Brain Cognitive Development (ABCD) Study subsample (N = 1,390; ages 9-13; 48% female) were compared. The participants were selected for hair selection through two methods: high scores on a substance risk algorithm selected 93%; 7% were low-risk, randomly selected participants. Kappa coefficients the examined concordance between self-report and hair results.<br><br>RESULTS: 10% of youth self-reported any past-year substance use (e.g. alcohol, cannabis, nicotine, and opiates), while a mostly non-overlapping 10% had hair results indicating recent substance use (cannabis, alcohol, non-prescription amphetamines, cocaine, nicotine, opiates, and fentanyl). In randomly selected low-risk cases, 7% were confirmed positive in hair. Combining methods, 19% of the sample self-reported substance use and/or had a positive hair sample. Kappa coefficient of concordance between self-report and hair results was low (kappa = 0.07; p = .007).<br><br>CONCLUSIONS: Hair toxicology identified substance use in high-risk and low-risk ABCD cohort subsamples. Given low concordance between hair results and self-report, reliance on either method alone would incorrectly categorize 9% as non-users. Multiple methods for characterizing substance use history in youth improves accuracy. Larger representative samples are needed to assess the prevalence of substance use in youth.<p /> <p>Language: en</p>",
language="en",
issn="0095-2990",
doi="10.1080/00952990.2023.2164931",
url="http://dx.doi.org/10.1080/00952990.2023.2164931"
}