@article{ref1,
title="Grip strength, gait speed, and trajectories of cognitive function in community-dwelling older adults: a prospective study",
journal="Alzheimer's and dementia: diagnosis, assessment and disease monitoring",
year="2023",
author="Wu, Zimu and Woods, Robyn L. and Chong, Trevor T.-J. and Orchard, Suzanne G. and Shah, Raj C. and Wolfe, Rory and Storey, Elsdon and Sheets, Kerry M. and Murray, Anne M. and McNeil, John J. and Ryan, Joanne",
volume="15",
number="1",
pages="e12388-e12388",
abstract="INTRODUCTION: This study investigated whether grip strength and gait speed predict cognitive aging trajectories and examined potential sex-specific associations. <br><br>METHODS: Community-dwelling older adults (n = 19,114) were followed for up to 7 years, with regular assessment of global function, episodic memory, psychomotor speed, and executive function. Group-based multi-trajectory modeling identified joint cognitive trajectories. Multinomial logistic regression examined the association of grip strength and gait speed at baseline with cognitive trajectories. <br><br>RESULTS: High performers (14.3%, n = 2298) and low performers (4.0%, n = 642) were compared to the average performers (21.8%, n = 3492). Grip strength and gait speed were positively associated with high performance and negatively with low performance (P-values < 0.01). The association between grip strength and high performance was stronger in women (interaction P < 0.001), while gait speed was a stronger predictor of low performance in men (interaction P < 0.05). <br><br>DISCUSSION: Grip strength and gait speed are associated with cognitive trajectories in older age, but with sex differences. HIGHLIGHTS: There is inter-individual variability in late-life cognitive trajectories.Grip strength and gait speed predicted cognitive trajectories in older age.However, sex-specific associations were identified.In women, grip strength strongly predicted high, compared to average, trajectory.In men, gait speed was a stronger predictor of low cognitive performance trajectory.<p /> <p>Language: en</p>",
language="en",
issn="2352-8729",
doi="10.1002/dad2.12388",
url="http://dx.doi.org/10.1002/dad2.12388"
}