@article{ref1,
title="Effect of physical activity intervention on gait speed by frailty condition: a randomized clinical trial",
journal="Journal of the American Medical Directors Association",
year="2023",
author="Custodero, Carlo and Agosti, Pasquale and Anton, Stephen D. and Manini, Todd M. and Lozupone, Madia and Panza, Francesco and Pahor, Marco and Sabbà, Carlo and Solfrizzi, Vincenzo",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="OBJECTIVES: There is uncertainty about effects of physical activity on physical performance, such as gait speed, among community-dwelling older adults according to their physical frailty status. We determined whether a long-term, moderate-intensity physical activity program was associated with different responses on gait speed over 4 m and 400 m based on physical frailty status. <br><br>DESIGN: Post hoc analysis from the Lifestyle Interventions and Independence for Elders (LIFE) (NCT01072500), a single-blind randomized clinical trial testing the effect of physical activity intervention compared with health education program. SETTING AND PARTICIPANTS: We analyzed data on 1623 community-dwelling older adults (78.9 ± 5.2 years) at risk for mobility disability. <br><br>METHODS: Physical frailty was assessed at baseline using the Study of Osteoporotic Fractures frailty index. Gait speed over 4 m and 400 m was measured at baseline, and 6, 12, and 24 months. <br><br>RESULTS: We estimated significantly better 400-m gait speed at 6, 12, and 24 months for nonfrail older adults in the physical activity group, but not for frail participants. Among frail participants, physical activity showed a potentially clinically meaningful benefit on 400-m gait speed at 6 months (0.055; 95% CI 0.016-0.094; P =.005), compared with the healthy educational intervention, only in those who, at baseline, were able to rise from a chair 5 times without using their arms. <br><br>CONCLUSIONS AND IMPLICATIONS: A well-structured physical activity program produced a faster 400-m gait speed potentially able to prevent mobility disability among physically frail individuals with preserved muscle strength in lower limbs.<p /> <p>Language: en</p>",
language="en",
issn="1525-8610",
doi="10.1016/j.jamda.2023.01.023",
url="http://dx.doi.org/10.1016/j.jamda.2023.01.023"
}