@article{ref1,
title="Associations of adolescent alcohol use and self-reported alcohol tolerance with risk of self-harm and suicide in early adulthood: a birth-cohort study",
journal="Journal of studies on alcohol and drugs",
year="2022",
author="Levola, Jonna and Denisoff, Alexander and Mustonen, Antti and Alakokkare, Anni-Emilia and Miettunen, Jouko and Bramness, Jørgen G. and Niemela, Solja",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="OBJECTIVE: We aimed to assess the predictive associations of age at first drink (AFD), age at first intoxication (AFI), frequency of intoxication, and self-reported alcohol tolerance at age 15-16 to self-harm requiring medical attention or suicide death by age 33. <br><br>METHOD: In an ongoing follow-up study, the Northern Finland Birth Cohort 1986, a total of 7,735 individuals were included at age 15-16. Information on alcohol and other substance use was assessed via questionnaires. Information on self-harm or suicide was collected from national registers until the participants were 33 years of age. Baseline psychiatric symptomatology measured with the Youth Self-Report questionnaire and socio-demographic background variables were controlled for in multivariable analyses using Cox regression analyses. <br><br>RESULTS: Male gender and psychiatric symptoms at age 15-16 were consistently associated with greater risk of self-harm and suicide death. When baseline psychiatric symptomatology and other background variables were adjusted for, younger AFI (Hazard Ratio, HR, 2.28. 95% CI 1.16-4.47) and high inherent alcohol tolerance (HR 3.76, 95% CI 1.55-9.08) were associated with self-harm. Furthermore, frequent alcohol intoxication (HR 5.39, 95% CI 1.44-20.23) and high inherent alcohol tolerance (HR 6.20, 95% CI 1.18-32.45) were associated with suicide death by age 33. <br><br>CONCLUSIONS: High alcohol tolerance, age of onset and frequency of alcohol intoxication in adolescence, appear to be significant predictors of self-harm and suicide in early adulthood. Self-reported alcohol tolerance in adolescence is a novel empirical approach to assess adolescent alcohol use associating with subsequent harms.<p /> <p>Language: en</p>",
language="en",
issn="1937-1888",
doi="10.15288/jsad.22-00055",
url="http://dx.doi.org/10.15288/jsad.22-00055"
}