@article{ref1,
title="Two cases reports: Severe liver injury caused by 1,2,3-trichloropropane poisoning",
journal="Frontiers in public health",
year="2023",
author="Li, Chen and Hu, Jinhua and Su, Haibin",
volume="11",
number="",
pages="e1171071-e1171071",
abstract="BACKGROUND: 1,2,3-trichloropropane (TCP) poisoning can induce liver damage in humans and animals, but reports of severe liver injury and its histology are rare. We presented two cases of 1,2,3-TCP inhalation poisoning resulting in severe liver injury confirmed by exposure history, toxicology, biochemical index and pathology.   CASE DESCRIPTION: Two young male presented acute poisoning process with mild to moderate early symptoms, and developed severe jaundice and coagulation dysfunction after exposure to 1,2,3-TCP. The total bilirubin (TBIL) in case 1 and case 2 reached the peak value of 635.8 μmol/L and 437.1 μmol/L on the 25th and 22nd days, respectively. Their liver enzymes and international normalized ratio increased rapidly to peak and fell back, and TBIL remained at a high level. 1,2,3-TCP was detected in their blood, and their liver histology indicated severe necrosis of hepatocytes, infiltration of massive inflammatory cells, and cholestasis. They all finally recovered after a long time of treatment. <br><br>CONCLUSION: The two cases in this study demonstrate that 1,2,3-TCP inhalation poisoning without any protective measures can induce severe liver injury in humans.<p /> <p>Language: en</p>",
language="en",
issn="2296-2565",
doi="10.3389/fpubh.2023.1171071",
url="http://dx.doi.org/10.3389/fpubh.2023.1171071"
}