@article{ref1,
title="Cortical hierarchy disorganization in major depressive disorder and its association with suicidality",
journal="Frontiers in psychiatry",
year="2023",
author="Shiwei, Lin and Xiaojing, Zhang and Yingli, Zhang and Shengli, Chen and Xiaoshan, Lin and Ziyun, Xu and Gangqiang, Hou and Yingwei, Qiu",
volume="14",
number="",
pages="e1140915-e1140915",
abstract="OBJECTIVES: To explore the suicide risk-specific disruption of cortical hierarchy in major depressive disorder (MDD) patients with diverse suicide risks. <br><br>METHODS: Ninety-two MDD patients with diverse suicide risks and 38 matched controls underwent resting-state functional MRI. Connectome gradient analysis and stepwise functional connectivity (SFC) analysis were used to characterize the suicide risk-specific alterations of cortical hierarchy in MDD patients. <br><br>RESULTS: Relative to controls, patients with suicide attempts (SA) had a prominent compression from the sensorimotor system; patients with suicide ideations (SI) had a prominent compression from the higher-level systems; non-suicide patients had a compression from both the sensorimotor system and higher-level systems, although it was less prominent relative to SA and SI patients. SFC analysis further validated this depolarization phenomenon. <br><br>CONCLUSION: This study revealed MDD patients had suicide risk-specific disruptions of cortical hierarchy, which advance our understanding of the neuromechanisms of suicidality in MDD patients.<p /> <p>Language: en</p>",
language="en",
issn="1664-0640",
doi="10.3389/fpsyt.2023.1140915",
url="http://dx.doi.org/10.3389/fpsyt.2023.1140915"
}