@article{ref1,
title="Probing the association between cognition, suicidal behavior and tryptophan metabolism in a sample of individuals living with bipolar disorder: a secondary analysis",
journal="Brain sciences",
year="2023",
author="Arru, Laura and Guiso, Beatrice and Garzilli, Mario and Congiu, Donatella and Bertazzo, Antonella and Manchia, Mirko and Comai, Stefano and Carpiniello, Bernardo and Pinna, Federica and Corrias, Carolina and Nasini, Sofia and Sut, Stefania and Dall'Acqua, Stefano and Meloni, Anna and Pisanu, Claudia and Squassina, Alessio and Paribello, Pasquale and Somaini, Giulia and Pinna, Ilaria and Iaselli, Maria Novella and Pulcinelli, Vittoria and Suprani, Federico",
volume="13",
number="4",
pages="-",
abstract="Background and Objectives: Alterations in hot cognition and in the tryptophan metabolism through serotonin (5-HT) and kynurenine (KYN) pathways have been associated with an increased risk of suicidal behavior. Here, we aim at probing the association between Stroop test performances and tryptophan pathway components in a sample of individuals with bipolar disorder (BD). <br><br>MATERIALS AND METHODS: We explored the association between the Emotion Inhibition Subtask (EIS) performances of the Brief Assessment of Cognition for Affective Disorders (BAC-A) and plasmatic levels of 5-hydroxytriptophan (5-HTP), 5-HT, KYN, 3-hydroxykynurenine (3-HK), quinolinic acid (QA), and kynurenic acid (KYNA) among subjects reporting lifetime suicide ideation (LSI) vs. non-LSI and subjects reporting lifetime suicide attempts (LSA) vs. non-LSA. <br><br>RESULTS: In a sample of 45 subjects with BD, we found a statistically significant different performance for LSA vs. non-LSA in the color naming (CN) and neutral words (NW) EIS subtasks. There was a significant association between CN performances and plasma 5-HTP levels among LSI and LSA subjects but not among non-LSI or non-LSA. <br><br>CONCLUSIONS: In our sample, patients with LSA and LSI presented lower performances on some EIS subtasks compared to non-LSA and non-LSI. Moreover, we found an inverse correlation between plasma 5-HTP concentration and some EIS performances in LSA and LSI but not among non-LSA or non-LSI. This may represent an interesting avenue for future studies probing this complex association.<p /> <p>Language: en</p>",
language="en",
issn="2076-3425",
doi="10.3390/brainsci13040693",
url="http://dx.doi.org/10.3390/brainsci13040693"
}