@article{ref1,
title="Gene-environment interaction between HPA-axis genes and trauma exposure in the suicide behavior: a systematic review",
journal="Journal of psychiatric research",
year="2023",
author="González-Castro, Thelma Beatriz and Juárez-Rojop, Isela Esther and Tovilla-Zárate, Carlos Alfonso and Ovando-Ricárdez, José Antonio and Hernández-Díaz, Yazmín and López-Narváez, María Lilia and Genis-Mendoza, Alma Delia and Rodríguez-Pérez, Candelario",
volume="164",
number="",
pages="162-170",
abstract="Suicide behavior (SB) emerge from complex interactions among traumatic events and multiple genetic factors. We conducted the first systematic review to assess the evidence of a link among trauma exposure, HPA-axis genes, and SB. A systematic search of PubMed, EBSCO, Science Direct, PsychInfo, and Scopus databases on gene-environment interaction, and susceptibility to SB was carried out until February 2022. Our study was prospectively registered in PROSPERO (CRD42022316141). A total of 13 epidemiological studies (11,756 subjects) were included: eight studies focused on traumatic experiences in the childhood and five studies on lifetime trauma exposure. All studies reported a positive association between the trauma exposure with SB. Gene-environment interaction was reported for CRHR1 (n = 6), CRHR2 (n = 2), FKBP5 (n = 2), and CRHBP (n = 1), however, for CRH, NR3C1, MC2R, and POMC genes no found gene-environment effects on SB. Trauma exposure could be one mechanism that links HPA-axis genes activity with the development of SB.<p /> <p>Language: en</p>",
language="en",
issn="0022-3956",
doi="10.1016/j.jpsychires.2023.06.011",
url="http://dx.doi.org/10.1016/j.jpsychires.2023.06.011"
}