@article{ref1,
title="Analysis of exposure characteristics and exposure rating of participants with injuries from CMIT/MIT humidifier disinfectants",
journal="Journal of environmental health sciences (Seoul)",
year="2023",
author="Min, Gihong and Shin, Junghyun and Jo, Eun-Kyung and Lee, Seula and Shin, Jihun and Kim, Dongjun and Woo, Jaemin and Choi, Yoon-Hyeong and Yang, Wonho",
volume="49",
number="3",
pages="169-177",
abstract="BACKGROUND: The Korea Centers for Disease Control and Prevention (KCDC) has identified cases of people suspected of suffering lung disease potentially caused by chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) used in humidifier disinfectants (HDs). The Korean Ministry of Environment (MoE) epidemiological investigation and toxicity test study found that HDs caused health damage such as asthma and lung disease.   Objectives: The main purposes of this study were to classify the HD exposure rating and to analyze the exposure characteristics that affect exposure to CMIT/MIT HDs.   Methods: The exposure characteristics and socio-demographic characteristics of victim participants using CMIT/MIT HDs were investigated through questionnaires. An inhalation no observed adverse effect level (NOAEL) for CMIT/MIT was produced based on inhalation toxicity values. Exposure ratings (class 1~class 2) were cross-tabulated with clinical ratings (acceptable~unacceptable). A correlation analysis was conducted with the main exposure characteristics that affect the exposure concentration of CMIT/MIT HDs.   Results: The concentration in indoor air of CMIT/MIT was 8.75±25.40 μg/m3, and the exposure concentration was 2.30±6.29 μg/m3. The CMIT/MIT exposure rating of 67 participants with high exposures of not more than MOE 100 were evaluated as 14.5%, while the damage participants who matched the clinical rating made up 4.5%. The exposure concentration of CMIT/MIT showed a positive correlation with the daily usage amount and usage frequency, and a negative correlation with volume of the indoor environment.   Conclusions: A new exposure rating could be suggested and calculated based on the MOE, and the factors affecting the exposure concentration could be identified.   Keywords Humidifier disinfectant, margin of exposure, chloromethylisothiazolinone/methylisothiazolinone, exposure rating<p /> <p>Language: en</p>",
language="en",
issn="1738-4087",
doi="10.5668/JEHS.2023.49.3.169",
url="http://dx.doi.org/10.5668/JEHS.2023.49.3.169"
}