@article{ref1,
title="Be aware of (R)-methamphetamine: negative immunoassay versus positive confirmation analysis",
journal="Drug testing and analysis",
year="2023",
author="Liut, Jennifer and Madea, Burkhard and Kramer, Michael and Maas-Gramlich, Alexandra",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="The amphetamine-type stimulant methamphetamine exists in two enantiomeric forms, (S)-methamphetamine and (R)-methamphetamine, which are both psychoactive but with the (S)-enantiomer being more potent than the (R)-enantiomer. Illicit methamphetamine encountered in Europe is typically a racemic mixture of both enantiomers and enantiopure (S)-methamphetamine, respectively. However, herein we report two cases with proven enantiopure (R)-methamphetamine consumption with moreover both cases remaining undetected by immunoassay screening. Inconspicuous immunoassay findings can be traced back to a considerably higher sensitivity and concentration-dependent cross-reactivity of the applied drug of abuse assay for the (S)-enantiomer of methamphetamine compared with the (R)-enantiomer, and this limitation should be well known by users of immunoassay drug tests.<p /> <p>Language: en</p>",
language="en",
issn="1942-7603",
doi="10.1002/dta.3556",
url="http://dx.doi.org/10.1002/dta.3556"
}