@article{ref1,
title="Progress and challenges in understanding disorders of consciousness following acute brain injury",
journal="Journal of integrative neuroscience",
year="2023",
author="Bagnato, Sergio",
volume="22",
number="4",
pages="e84-e84",
abstract="Severe acute brain injuries can give rise to different disorders of consciousness (DoC), including coma in the acute phase, vegetative state or unresponsive wakefulness syndrome (VS/UWS), and minimally conscious state (MCS) during the post-acute phase. Despite significant progress in understanding DoC, a precise forecasting of consciousness recovery remains a challenge. This is primarily due to the difficulties in assessing the integrity of neural circuits that support consciousness and to the limited understanding of the synaptic, neuronal, and system-level mechanisms of brain plasticity that are involved in consciousness recovery [1]. Additionally, the prospect of long-term secondary neurodegeneration further complicates the chances for recovery [2]. Consequently, therapeutic interventions aimed at restoring consciousness often lack specificity and, hence, may only achieve limited outcomes [3]. Furthermore, while a standardized neurobehavioral assessment is required to distinguish between VS/UWS and MCS patients [4], it may underestimate the patient's responsiveness and lead to incorrect VS/UWS diagnoses, especially in cases of severe visual, language, or motor impairments...<p /> <p>Language: en</p>",
language="en",
issn="0219-6352",
doi="10.31083/j.jin2204084",
url="http://dx.doi.org/10.31083/j.jin2204084"
}