@article{ref1,
title="GWAS meta-analysis of suicide attempt: identification of 12 genome-wide significant loci and implication of genetic risks for specific health factors",
journal="American journal of psychiatry",
year="2023",
author="Docherty, Anna R. and Mullins, Niamh and Ashley-Koch, Allison E. and Qin, Xuejun and Coleman, Jonathan R. I. and Shabalin, Andrey and Kang, JooEun and Murnyak, Balasz and Wendt, Frank and Adams, Mark and Campos, Adrian I. and DiBlasi, Emily and Fullerton, Janice M. and Kranzler, Henry R. and Bakian, Amanda V. and Monson, Eric T. and Renteria, Miguel E. and Walss-Bass, Consuelo and Andreassen, Ole A. and Behera, Chittaranjan and Bulik, Cynthia M. and Edenberg, Howard J. and Kessler, Ronald C. and Mann, J. John and Nurnberger, John I. Jr and Pistis, Giorgio and Streit, Fabian and Ursano, Robert J. and Polimanti, Renato and Dennis, Michelle and Garrett, Melanie and Hair, Lauren and Harvey, Philip and Hauser, Elizabeth R. and Hauser, Michael A. and Huffman, Jennifer and Jacobson, Daniel and Madduri, Ravi and McMahon, Benjamin and Oslin, David W. and Trafton, Jodie and Awasthi, Swapnil and Berrettini, Wade H. and Bohus, Martin and Chang, Xiao and Chen, Hsi-Chung and Chen, Wei J. and Christensen, Erik D. and Crow, Scott and Duriez, Philibert and Edwards, Alexis C. and Fernández-Aranda, Fernando and Galfalvy, Hanga and Gandal, Michael and Gorwood, Philip and Guo, Yiran and Hafferty, Jonathan D. and Hakonarson, Hakon and Halmi, Katherine A. and Hishimoto, Akitoyo and Jain, Sonia and Jamain, Stéphane and Jimenez-Murcia, Susana and Johnson, Craig and Kaplan, Allan S. and Kaye, Walter H. and Keel, Pamela K. and Kennedy, James L. and Kim, Minsoo and Klump, Kelly L. and Levey, Daniel F. and Li, Dong and Liao, Shih-Cheng and Lieb, Klaus and Lilenfeld, Lisa and Marshall, Christian R. and Mitchell, James E. and Okazaki, Satoshi and Otsuka, Ikuo and Pinto, Dalila and Powers, Abigail and Ramoz, Nicolas and Ripke, Stephan and Roepke, Stefan and Rozanov, Vsevolod and Scherer, Stephen W. and Schmahl, Christian and Sokolowski, Marcus and Starnawska, Anna and Strober, Michael and Su, Mei-Hsin and Thornton, Laura M. and Treasure, Janet and Ware, Erin B. and Watson, Hunna J. and Witt, Stephanie H. and Woodside, D. Blake and Yilmaz, Zeynep and Zillich, Lea and Adolfsson, Rolf and Agartz, Ingrid and Alda, Martin and Alfredsson, Lars and Appadurai, Vivek and Artigas, María Soler and Van der Auwera, Sandra and Azevedo, M. Helena and Bass, Nicholas and Bau, Claiton H. D. and Baune, Bernhard T. and Bellivier, Frank and Berger, Klaus and Biernacka, Joanna M. and Bigdeli, Tim B. and Binder, Elisabeth B. and Boehnke, Michael and Boks, Marco P. and Braff, David L. and Bryant, Richard and Budde, Monika and Byrne, Enda M. and Cahn, Wiepke and Castelao, Enrique and Cervilla, Jorge A. and Chaumette, Boris and Corvin, Aiden and Craddock, Nicholas and Djurovic, Srdjan and Foo, Jerome C. and Forstner, Andreas J. and Frye, Mark and Gatt, Justine M. and Giegling, Ina and Grabe, Hans J. and Green, Melissa J. and Grevet, Eugenio H. and Grigoroiu-Serbanescu, Maria and Gutiérrez, Blanca and Guzman-Parra, Jose and Hamshere, Marian L. and Hartmann, Annette M. and Hauser, Joanna and Heilmann-Heimbach, Stefanie and Hoffmann, Per and Ising, Marcus and Jones, Ian and Jones, Lisa A. and Jonsson, Lina and Kahn, Rene S. and Kelsoe, John R. and Kendler, Kenneth S. and Kloiber, Stefan and Koenen, Karestan C. and Kogevinas, Manolis and Krebs, Marie-Odile and Landén, Mikael and Leboyer, Marion and Lee, Phil H. and Levinson, Douglas F. and Liao, Calwing and Lissowska, Jolanta and Mayoral, Fermín and McElroy, Susan L. and McGrath, Patrick and McGuffin, Peter and McQuillin, Andrew and Mehta, Divya and Melle, Ingrid and Mitchell, Philip B. and Molina, Esther and Morken, Gunnar and Nievergelt, Caroline and Nothen, Markus M. and O'Donovan, Michael C. and Ophoff, Roel A. and Owen, Michael J. and Pato, Carlos and Pato, Michele T. and Penninx, Brenda W. J. H. and Potash, James B. and Power, Robert A. and Preisig, Martin and Quested, Digby and Ramos-Quiroga, Josep Antoni and Reif, Andreas and Ribasés, Marta and Richarte, Vanesa and Rietschel, Marcella and Rivera, Margarita and Roberts, Andrea and Roberts, Gloria and Rouleau, Guy A. and Rovaris, Diego L. and Sanders, Alan R. and Schofield, Peter R. and Schulze, Thomas G. and Scott, Laura J. and Serretti, Alessandro and Shi, Jianxin and Sirignano, Lea and Sklar, Pamela and Smeland, Olav B. and Smoller, Jordan W. and Sonuga-Barke, Edmund J. S. and Trzaskowski, Maciej and Tsuang, Ming T. and Turecki, Gustavo and Vilar-Ribó, Laura and Vincent, John B. and Völzke, Henry and Walters, James T. R. and Weickert, Cynthia Shannon and Weickert, Thomas W. and Weissman, Myrna M. and Williams, Leanne M. and Wray, Naomi R. and Zai, Clement C. and Agerbo, Esben and Børglum, Anders D. and Breen, Gerome and Demontis, Ditte and Erlangsen, Annette and Gelernter, Joel and Glatt, Stephen J. and Hougaard, David M. and Hwu, Hai-Gwo and Kuo, Po-Hsiu and Lewis, Cathryn M. and Li, Qingqin S. and Liu, Chih-Min and Martin, Nicholas G. and McIntosh, Andrew M. and Medland, Sarah E. and Mors, Ole and Nordentoft, Merete and Olsen, Catherine M. and Porteous, David and Smith, Daniel J. and Stahl, Eli A. and Stein, Murray B. and Wasserman, Danuta and Werge, Thomas and Whiteman, David C. and Willour, Virginia and Coon, Hilary and Beckham, Jean C. and Kimbrel, Nathan A. and Ruderfer, Douglas M.",
volume="180",
number="10",
pages="723-738",
abstract="OBJECTIVE: Suicidal behavior is heritable and is a major cause of death worldwide. Two large-scale genome-wide association studies (GWASs) recently discovered and cross-validated genome-wide significant (GWS) loci for suicide attempt (SA). The present study leveraged the genetic cohorts from both studies to conduct the largest GWAS meta-analysis of SA to date. Multi-ancestry and admixture-specific meta-analyses were conducted within groups of significant African, East Asian, and European ancestry admixtures. <br><br>METHODS: This study comprised 22 cohorts, including 43,871 SA cases and 915,025 ancestry-matched controls. Analytical methods across multi-ancestry and individual ancestry admixtures included inverse variance-weighted fixed-effects meta-analyses, followed by gene, gene-set, tissue-set, and drug-target enrichment, as well as summary-data-based Mendelian randomization with brain expression quantitative trait loci data, phenome-wide genetic correlation, and genetic causal proportion analyses. <br><br>RESULTS: Multi-ancestry and European ancestry admixture GWAS meta-analyses identified 12 risk loci at p values <5×10(-8). These loci were mostly intergenic and implicated DRD2, SLC6A9, FURIN, NLGN1, SOX5, PDE4B, and CACNG2. The multi-ancestry SNP-based heritability estimate of SA was 5.7% on the liability scale (SE=0.003, p=5.7×10(-80)). Significant brain tissue gene expression and drug set enrichment were observed. There was shared genetic variation of SA with attention deficit hyperactivity disorder, smoking, and risk tolerance after conditioning SA on both major depressive disorder and posttraumatic stress disorder. Genetic causal proportion analyses implicated shared genetic risk for specific health factors. <br><br>CONCLUSIONS: This multi-ancestry analysis of suicide attempt identified several loci contributing to risk and establishes significant shared genetic covariation with clinical phenotypes. These findings provide insight into genetic factors associated with suicide attempt across ancestry admixture populations, in veteran and civilian populations, and in attempt versus death.<p /> <p>Language: en</p>",
language="en",
issn="0002-953X",
doi="10.1176/appi.ajp.21121266",
url="http://dx.doi.org/10.1176/appi.ajp.21121266"
}