@article{ref1,
title="Response to letter to the editors regarding 'a meta-regression of trial features predicting the effects of alcohol use disorder pharmacotherapies on drinking outcomes in randomized clinical trials: a secondary data analysis'",
journal="Alcohol and alcoholism",
year="2023",
author="Grodin, Erica N. and Donato, Suzanna and Du, Han and Green, ReJoyce and Bujarski, Spencer and Ray, Lara A.",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="We received and read the letter to the Editors from Drs Guiraud and van den Brink regarding our article entitled 'A Meta-Regression of Trial Features Predicting the Effects of Alcohol Use Disorder Pharmacotherapies on Drinking Outcomes in Randomized Clinical Trials: A Secondary Data Analysis'.   We believe that the comments provided by the authors are derived from differing findings in their recently published paper 'Sodium Oxybate for Alcohol Dependence: A Network Meta-Regression Analysis Considering Population Severity at Baseline and Treatment Duration'. We would like to highlight that the two manuscripts took different approaches to answer different questions. Our manuscript used a meta-regression approach with two arms (pharmacotherapy treatment vs. control) to answer the question of what trial features predict the efficacy of pharmacotherapies on drinking outcomes across a range of 19 pharmacotherapies. Guiraud et al. used a network meta-regression approach focused solely on one pharmacotherapy, sodium oxybate, as a treatment for alcohol use disorder. It is therefore unsurprising that different methodological approaches to solve different questions resulted in different answers...<p /> <p>Language: en</p>",
language="en",
issn="0735-0414",
doi="10.1093/alcalc/agad066",
url="http://dx.doi.org/10.1093/alcalc/agad066"
}