@article{ref1,
title="Atypical interpersonal problem-solving and resting-state functional connectivity in adolescents with maltreatment experience",
journal="Current neuropharmacology",
year="2023",
author="Gerin, Mattia I. and Viding, Essi and Puetz, Vanessa B. and Armbruster-Genç, Diana J. N. and Rankin, Georgia and McCrory, Eamon J.",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="BACKGROUND: Childhood maltreatment is associated with altered neurocognitive functioning, which is thought to reflect, in part, adaptation to early adverse environmental experiences. However, we continue to lack a precise mechanistic understanding linking atypical neurocognitive processing with social functioning and psychiatric outcomes following early adversity. <br><br>OBJECTIVE: The present work investigated interpersonal problem-solving, resting-state functional connectivity (rsFC), and mental health symptoms in adolescents with documented maltreatment experience and explored whether altered neural function contributes in part to poorer social functioning. <br><br>METHODS: Forty adolescents (aged 12-17) with documented experiences of abuse or neglect and a carefully matched group of 42 non-maltreated peers participated in this study that measured task-based interpersonal problem-solving skills and rsFC. <br><br>RESULTS: Adolescents with maltreatment experience showed poorer interpersonal problem-solving performance, which partly accounted for their elevated mental health symptoms. Resting-state seed-based analyses revealed that adolescents with maltreatment experience showed a significant increase in rsFC between medial Default Mode Network (DMN) hubs, the medial prefrontal cortex (mPFC), with a posterior cluster, including the posterior cingulate cortex (PCC), precuneus (PCu), retrosplenial cortex (RSC), and lingual gyrus (LG). Moderation analyses revealed that maltreatment-related increased DMN rsFC partly accounted for poorer performance in interpersonal problem-solving. <br><br>CONCLUSION: Poorer interpersonal problem-solving, partly accounted for by atypical coupling between DMN medial hubs, was associated with maltreatment exposure. Interventions tailored to enhance interpersonal problem-solving represents a promising avenue to promote resilience and reduce the likelihood of mental health disorder following maltreatment experience.<p /> <p>Language: en</p>",
language="en",
issn="1570-159X",
doi="10.2174/1570159X22666231002145440",
url="http://dx.doi.org/10.2174/1570159X22666231002145440"
}