@article{ref1,
title="Biokinetic model analysis with DTPA administration for a case of accidental inhalation of actinides in Japan",
journal="Radiation protection dosimetry",
year="2023",
author="Tani, Kotaro and Ishigure, Nobuhito and Kim, Eunjoo and Tominaga, Takako and Tatsuzaki, Hideo and Akashi, Makoto and Kurihara, Osamu",
volume="199",
number="15-16",
pages="2025-2029",
abstract="Accidental inhalation intake of plutonium isotopes and 241Am occurred at a Pu research facility in Japan in 2017, and the five workers involved in this accident were treated by the administration of Ca/Zn-diethylenetriaminepentaacetic acid (DTPA). For the worker who was most internally exposed, the therapy was continued over 1 y after the accident. Urinary samples collected before and after each administration were subject to bioassay to evaluate the efficacy of the dose reduction. This study performed numerical analyses using a biokinetic model dealing with 241Am-DTPA with reference to the European Coordinated Network on Radiation Dosimetry approach, which assumes that the complex of actinides and Ca/Zn-DTPA is generated in the designated compartments in the biokinetic model. The results of the model prediction well captured the trend of the observed urinary excretion in the long-term bioassay and would be useful to evaluate the efficacy of the Ca/Zn-DTPA administration for the worker involved in the accident.<p /> <p>Language: en</p>",
language="en",
issn="0144-8420",
doi="10.1093/rpd/ncac224",
url="http://dx.doi.org/10.1093/rpd/ncac224"
}