@article{ref1,
title="Relationship between evacuation after the Great East Japan Earthquake and new-onset hyperuricemia: a 7-year prospective longitudinal study of the Fukushima Health Management Survey",
journal="PLoS one",
year="2023",
author="Honda, Kazuya and Okazaki, Kanako and Tanaka, Kenichi and Kobari, Eri and Kazama, Sakumi and Hashimoto, Shigeatsu and Ohira, Tetsuya and Sakai, Akira and Yasumura, Seiji and Maeda, Masaharu and Yabe, Hirooki and Hosoya, Mitsuaki and Takahashi, Atsushi and Harigane, Mayumi and Nakano, Hironori and Hayashi, Fumikazu and Nagao, Masanori and Shimabukuro, Michio and Ohto, Hitoshi and Kamiya, Kenji and Kazama, Junichiro J.",
volume="18",
number="10",
pages="e0293459-e0293459",
abstract="INTRODUCTION: On March 11, 2011, the Great East Japan Earthquake occurred in Japan, with a nuclear accident subsequently occurring at the Fukushima Daiichi Nuclear Power Plant. The disaster forced many evacuees to change particular aspects of their lifestyles. However, the effect of evacuation on the new-onset of hyperuricemia have not been sufficiently elucidated. This study assessed the association between evacuation and new-onset hyperuricemia after the earthquake based on the Fukushima Health Management Survey from a lifestyle and socio-psychological perspective. <br><br>MATERIALS AND METHODS: This is a 7-year prospective longitudinal study included 18,140 residents (6,961 men and 11,179 women) with non-hyperuricemia who underwent both the Comprehensive Health Check and the Mental Health and Lifestyle Survey in fiscal year 2011. Associations between new-onset hyperuricemia and lifestyle- and disaster-related factors, including evacuation, were estimated using a Cox proportional hazards regression model analysis. Hyperuricemia was defined as uric acid levels > 7.0 mg/dL for men and > 6.0 mg/dL for women. <br><br>RESULTS: During a median follow-up of 4.3 years, 2,996 participants (1,608 men, 23.1%, 1,388 women, 12.4%) newly developed hyperuricemia. Significant associations were observed between evacuation and onset of hyperuricemia in women (adjusted hazard ratio 1.18, 95% confidence interval, 1.05-1.32, p = 0.007), but not in men (adjusted hazard ratio 1.11, 95% confidence interval, 0.99-1.24, p = 0.067). <br><br>DISCUSSION: Evacuation after a natural disaster is an independent risk factor for the new-onset of hyperuricemia in women. The possibility of hyperuricemia developing in response to natural disasters should be considered.<p /> <p>Language: en</p>",
language="en",
issn="1932-6203",
doi="10.1371/journal.pone.0293459",
url="http://dx.doi.org/10.1371/journal.pone.0293459"
}