@article{ref1,
title="Brief report: The influence of childhood trauma on the effects of delta-9-tetrahydrocannabinol in persons with opioid use disorder",
journal="American journal on addictions",
year="2023",
author="Rogan, Michael and Nunes, Julio C. and Xie, Catherine Z. and Sofuoglu, Mehmet and Pittman, Brian and De Aquino, Joao P.",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="BACKGROUND AND OBJECTIVES: Childhood trauma (CT) increases addiction vulnerability. We examined CT's impact on delta-9-tetrahydrocannabinol (THC) effects. <br><br>METHODS: This is a post-hoc analysis of a randomized, placebo-controlled, crossover trial investigating the effects of oral THC (10, 20 mg) among 25 persons receiving methadone for opioid use disorder (OUD). <br><br>RESULTS: Greater CT was associated with lower aversive effects from higher THC doses (20 mg) (p = .006). <br><br>DISCUSSION AND CONCLUSIONS: CT may reduce the subjective aversive effects of THC, potentially leading to greater cannabis use in individuals with OUD. SCIENTIFIC SIGNIFICANCE: These findings offer insights into THC's risks versus benefits in OUD subgroups and emphasize assessing CT in OUD treatment and research.<p /> <p>Language: en</p>",
language="en",
issn="1055-0496",
doi="10.1111/ajad.13504",
url="http://dx.doi.org/10.1111/ajad.13504"
}