@article{ref1,
title="Early intervention treatment in the first 2 weeks following concussion in adults: a systematic review of randomised controlled trials",
journal="Physical therapy in sport",
year="2023",
author="Moore, Sonya and Musgrave, Chris and Sandler, Jonathan and Bradley, Ben and Jones, Jennifer R. A.",
volume="65",
number="",
pages="59-73",
abstract="OBJECTIVE: International guidelines support a repertoire of therapeutic interventions that may assist recovery following concussion. We aimed to systematically review the efficacy of early pharmacological and non-pharmacological interventions initiated within two weeks of injury on symptoms and functional recovery of adults with concussion. <br><br>METHODS: We conducted a Systematic Review (SR) of Randomised Controlled Trials (RCTs) without meta-analysis utilising the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A comprehensive search was performed of four databases. Study inclusion criteria were adult participants diagnosed with concussion and commencing active intervention within 14 days of injury. <br><br>RESULTS AND CONCLUSIONS: Of 7531 studies identified, 11 were included in the final review. Six studies were rated as high-risk of bias, three with some concerns and two as low-risk of bias. We found no evidence to support specific pharmacotherapeutic management to hasten the natural recovery time-course. Two studies reported significant improvement in selected concussion symptoms following manual therapy (at 48-72 hours post-treatment) or telephone counselling interventions (at 6 months post-injury). No high quality RCTs demonstrate superior effects of early therapeutic interventions on concussion recovery in the first 2 weeks. We advocate future research to examine impacts of health-clinician contact points aligned with symptom-specific interventions.<p /> <p>Language: en</p>",
language="en",
issn="1466-853X",
doi="10.1016/j.ptsp.2023.11.005",
url="http://dx.doi.org/10.1016/j.ptsp.2023.11.005"
}