@article{ref1,
title="Can inhaled cannabis users accurately evaluate impaired driving ability? A randomized controlled trial",
journal="Frontiers in public health",
year="2023",
author="Hartley, Sarah and Simon, Nicolas and Cardozo, Bibiana and Larabi, Islam Amine and Alvarez, Jean Claude",
volume="11",
number="",
pages="e1234765-e1234765",
abstract="AIMS: To study the effect of inhaled cannabis on self-assessed predicted driving ability and its relation to reaction times and driving ability on a driving simulator. PARTICIPANTS AND METHODS: 30 healthy male volunteers aged 18-34: 15 chronic (1-2 joints /day) and 15 occasional (1-2 joints/week) consumers. Self-assessed driving confidence (visual analog scale), vigilance (Karolinska), reaction time (mean reciprocal reaction time mRRT, psychomotor vigilance test), driving ability (standard deviation of lane position SDLP on a York driving simulator) and blood concentrations of delta-9-tétrahydrocannabinol (THC) were measured before and repeatedly after controlled inhalation of placebo, 10 mg or 30 mg of THC mixed with tobacco in a cigarette. <br><br>RESULTS: Cannabis consumption (at 10 and 30 mg) led to a marked decrease in driving confidence over the first 2 h which remained below baseline at 8 h. Driving confidence was related to THC dose and to THC concentrations in the effective compartment with a low concentration of 0.11 ng/ml for the EC50 and a rapid onset of action (T1/2 37 min). Driving ability and reaction times were reduced by cannabis consumption. Driving confidence was shown to be related to driving ability and reaction times in both chronic and occasional consumers. <br><br>CONCLUSIONS: Cannabis consumption leads to a rapid reduction in driving confidence which is related to reduced ability on a driving simulator.   CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, identifier: NCT02061020.  Keywords: Cannabis impaired driving <p /> <p>Language: en</p>",
language="en",
issn="2296-2565",
doi="10.3389/fpubh.2023.1234765",
url="http://dx.doi.org/10.3389/fpubh.2023.1234765"
}