@article{ref1,
title="Coniin, in Five Little Pigs",
journal="Brain and nerve",
year="2023",
author="Sakai, Kuniyoshi L.",
volume="75",
number="12",
pages="1319-1323",
abstract="In this manuscript, I provide some insights into the novel Five Little Pigs (US title: Murder in Retrospect) by Agatha Christie, and overview the neurotoxin coniine that plays an essential role in that story. Coniine is a nicotinic acetylcholine receptor antagonist, and induces a slowly spreading effect of paralysis by acting directly on the peripheral nervous system. This agent has been used as a poison for thousands of years; indeed, the philosophical text Phaedo describes that coniine was used to put Socrates to death. Based on this background, Christie's views on human nature and her creative powers are also discussed.   ===   本論では，アガサ・クリスティーによる小説『五匹の子豚』を読み解き，その作中で重要な役割を果たす神経毒「コニイン」について概観する。コニインはニコチン性アセチルコリン受容体の拮抗薬であり，末梢神経系に直接作用して遅効性の麻痺を引き起こす。この毒薬の歴史は古く，ソクラテスの刑死に使われたことが哲学書『パイドン』に描かれている。そうした背景を踏まえて，クリスティーの人間観や創造力についても議論する。  Copyright © 2023, Igaku-Shoin Ltd. All rights reserved.<p /> <p>Language: ja</p>",
language="ja",
issn="1881-6096",
doi="10.11477/mf.1416202531",
url="http://dx.doi.org/10.11477/mf.1416202531"
}