@article{ref1,
title="To be or not to be: the active inference of suicide",
journal="Neuroscience and biobehavioral reviews",
year="2024",
author="Krupnik, Valery and Danilova, Nadia",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="Suicide presents an apparent paradox as a behavior whose motivation is not obvious since its outcome is non-existence and cannot be experienced. To address this paradox, we propose to frame suicide in the integrated theory of stress and active inference. We present an active inference-based cognitive model of suicide as a type of stress response hanging in cognitive balance between predicting self-preservation and self-destruction. In it, self-efficacy emerges as a meta-cognitive regulator that can bias the model toward either survival or suicide. The model suggests conditions under which cognitive homeostasis can override physiological homeostasis in motivating self-destruction. We also present a model proto-suicidal behavior, programmed cell death (apoptosis), in active inference terms to illustrate how an active inference model of self-destruction can be embodied in molecular mechanisms and to offer a hypothesis on another puzzle of suicide: why only humans among brain-endowed animals are known to practice it.<p /> <p>Language: en</p>",
language="en",
issn="0149-7634",
doi="10.1016/j.neubiorev.2023.105531",
url="http://dx.doi.org/10.1016/j.neubiorev.2023.105531"
}