@article{ref1,
title="Posterior hypothalamic region deep brain stimulation for the treatment of aggression disorders in patients with intellectual disability: a systematic review",
journal="Stereotactic and functional neurosurgery",
year="2024",
author="Cojazzi, Vittoria and Innocenti, Niccolò and Castelli, Nicolò and Levi, Vincenzo and Nazzi, Vittoria and Lozano, Andres and Rizzi, Michele",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="INTRODUCTION: Aggressive disorders, in patients with intellectual disability, are satisfactorily managed with an educational, psychological, and pharmacological approach. Posterior hypothalamic region deep brain stimulation emerged in the last two decades as a promising treatment for patients with severe aggressive disorders. However, limited experiences are reported in the literature. <br><br>METHODS: A systematic review was performed following PRISMA guidelines and recommendations by querying PubMed and Embase on August 24th, 2022, with the ensuing string parameters: ([deep brain stimulation] OR [DBS]) AND ([aggressiv*] OR disruptive). Cochrane Library, DynaMed, and ClinicalTrials.gov were consulted using the combination of keywords &quot;deep brain stimulation&quot; and &quot;aggressive&quot; or &quot;aggression&quot;. The clinical outcome at the last follow-up and the rate of complications were considered primary and secondary outcomes of interest. <br><br>RESULTS: The initial search identified 1,080 records, but only 10 studies met the inclusion criteria and were considered. The analysis of clinical outcome and complications was therefore performed on a total of 60 patients. Quality of all selected studies was classified as high, but one. Mean Overt Aggression Scale (OAS) improvement was 68%, while Inventory for Client Agency Planning (ICAP) improvement ranged between 38.3% and 80%. Complications occurred in 4 patients (6.7%). <br><br>CONCLUSION: Posterior hypothalamic region deep brain stimulation may be considered a valuable option for patients with severe aggression disorders and ID. This review can represent a mainstay for those who will be engaged in the surgical treatment of these patients.<p /> <p>Language: en</p>",
language="en",
issn="1011-6125",
doi="10.1159/000535105",
url="http://dx.doi.org/10.1159/000535105"
}