@article{ref1,
title="Suicide attempts after a diagnosis of polycystic ovary syndrome : a cohort study",
journal="Annals of internal medicine",
year="2024",
author="Hsu, Tien-Wei and Kao, Yu-Chen and Tsai, Shih-Jen and Bai, Ya-Mei and Su, Tung-Ping and Chen, Tzeng-Ji and Liang, Chih-Sung and Chen, Mu-Hong",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="BACKGROUND: Limited evidence exists about suicide risk in persons with polycystic ovary syndrome (PCOS). <br><br>OBJECTIVE: To assess suicide risk in persons with PCOS, accounting for psychiatric comorbid conditions and age group. <br><br>DESIGN: Cohort study. SETTING: Data from the Taiwanese nationwide database from 1997 to 2012. PATIENTS: A cohort of 18 960 patients diagnosed with PCOS, each matched with control participants in a 1:10 ratio on the basis of age, psychiatric comorbid conditions, urbanization level, and income. Suicide attempts were evaluated using Cox regression models. MEASUREMENTS: Suicide risk with hazard ratios (HRs). <br><br>RESULTS: Participants with PCOS had a notable 8.47-fold increase in risk for suicide attempt compared with the control group (HR, 8.47 [95% CI, 7.54 to 9.51]), after adjustment for demographic characteristics, psychiatric comorbid conditions, Charlson Comorbidity Index scores, and frequency of all-cause clinical visits. The elevated risk was evident across the adolescent (HR, 5.38 [CI, 3.93 to 7.37]), young adult (<40 years; HR, 9.15 [CI, 8.03 to 10.42]), and older adult (HR, 3.75 [CI, 2.23 to 6.28]) groups. Sensitivity analyses involving the exclusion of data from the first year or the first 3 years of observation yielded consistent results. LIMITATION: Potential underestimation of PCOS and mental disorder prevalence due to use of administrative claims data; lack of clinical data, such as body mass index and depressive symptoms; and no assessment of a confounding effect of valproic acid exposure. <br><br>CONCLUSION: This study underscores the heightened risk for suicide attempt that persons with PCOS face, even after adjustment for demographics, psychiatric comorbid conditions, physical conditions, and all-cause clinical visits. This suggests the importance of routine monitoring of mental health and suicide risk in persons diagnosed with PCOS. PRIMARY FUNDING SOURCE: Taipei Veterans General Hospital, Yen Tjing Ling Medical Foundation, and Ministry of Science and Technology of Taiwan.<p /> <p>Language: en</p>",
language="en",
issn="0003-4819",
doi="10.7326/M23-2240",
url="http://dx.doi.org/10.7326/M23-2240"
}