@article{ref1,
title="Adolescent social isolation increases binge-like alcohol drinking in male but not female high-alcohol-preferring mice",
journal="Alcohol and alcoholism",
year="2024",
author="Cullins, Eva C. and Chester, Julia A.",
volume="59",
number="2",
pages="agae006-agae006",
abstract="AIMS: This study examined how adolescent social isolation affects adult binge-like alcohol drinking and stress-axis function, via basal levels of circulating corticosterone (CORT), in male and female mice with a genetic predisposition toward high alcohol preference (HAP). <br><br>METHODS: Male and female HAP2 mice were randomly assigned to a group-housed or social isolation (ISO) group. Social isolation began at postnatal Days 40-42 and lasted for 21 days prior to assessment of binge-like alcohol drinking using a 4-day drinking-in-the-dark (DID) procedure. Blood samples to assess basal CORT were taken 6 days after social isolation ended and 24 h before DID started, and again 60 h after DID ended, during the light portion of the light cycle. <br><br>RESULTS: Adolescent social isolation increased adult binge-like alcohol drinking in male but not female mice. All groups showed significantly lower CORT after DID compared to before DID. Pearson bivariate correlation coefficients between the first 2 h of grams-per-kilogram alcohol intake on Day 4 and CORT levels indicated a significant positive correlation in ISO males only after DID and negative correlations in ISO females before and after DID. <br><br>CONCLUSIONS: These findings demonstrate that adolescent social isolation increased binge-like alcohol drinking in male but not female adult HAP2 mice. Stress-axis adaptations in male HAP2 mice may be associated with the social-isolation-induced increase in binge-like alcohol drinking.<p /> <p>Language: en</p>",
language="en",
issn="0735-0414",
doi="10.1093/alcalc/agae006",
url="http://dx.doi.org/10.1093/alcalc/agae006"
}