@article{ref1,
title="Mean corpuscular volume as a prognostic factor for 30-day mortality in major trauma patients: a retrospective cohort study",
journal="Scientific reports",
year="2024",
author="Choi, Hanlim and Lee, Jin Young and Sul, Younghoon and Kim, Se Heon and Ye, Jin Bong and Lee, Jin Suk and Yoon, Soo Young and Seok, Junepill and Choi, Jung Hee",
volume="14",
number="1",
pages="e3951-e3951",
abstract="We investigated the clinical implications of the mean corpuscular volume (MCV) in patients with major trauma. This single-center retrospective review included 2021 trauma patients admitted to the intensive care unit between January 2016 and June 2020. We included 1218 patients aged [Formula: see text] 18 years with an injury severity score [Formula: see text] 16 in the final analysis. The clinical and laboratory variables were compared between macrocytosis (defined as MCV [Formula: see text] 100 fL) and non-macrocytosis groups. Cox regression analysis was performed to calculate the hazard ratios (HRs) of variables for 30-day mortality, with adjustment for other potential confounding factors. The initial mean value of MCV was 102.7 fL in the macrocytosis group (n = 199) and 93.7 fL in the non-macrocytosis group (n = 1019). The macrocytosis group showed a significantly higher proportion of initial hypotension, transfusion within 4 and 24 h, and 30-day mortality than the non-macrocytosis group. Age ([Formula: see text] 65 years), hypotension (systolic blood pressure [Formula: see text] 90 mmHg), transfusion (within 4 h), anemia (Hb < 12 g/day in women, < 13 g/day in men), and macrocytosis were significantly associated with 30-day mortality (adjusted HR = 1.4; 95% confidence interval 1.01-1.94; p = 0.046) in major trauma patients. Thus, initial macrocytosis independently predicted 30-day mortality in patients with major trauma at a Level I trauma center.<p /> <p>Language: en</p>",
language="en",
issn="2045-2322",
doi="10.1038/s41598-024-54057-1",
url="http://dx.doi.org/10.1038/s41598-024-54057-1"
}