@article{ref1,
title="Neuronal dynamics direct cerebrospinal fluid perfusion and brain clearance",
journal="Nature",
year="2024",
author="Jiang-Xie, Li-Feng and Drieu, Antoine and Bhasiin, Kesshni and Quintero, Daniel and Smirnov, Igor and Kipnis, Jonathan",
volume="627",
number="8002",
pages="157-164",
abstract="The accumulation of metabolic waste is a leading cause of numerous neurological disorders, yet we still have only limited knowledge of how the brain performs self-cleansing. Here we demonstrate that neural networks synchronize individual action potentials to create large-amplitude, rhythmic and self-perpetuating ionic waves in the interstitial fluid of the brain. These waves are a plausible mechanism to explain the correlated potentiation of the glymphatic flow1,2 through the brain parenchyma. Chemogenetic flattening of these high-energy ionic waves largely impeded cerebrospinal fluid infiltration into and clearance of molecules from the brain parenchyma. Notably, synthesized waves generated through transcranial optogenetic stimulation substantially potentiated cerebrospinal fluid-to-interstitial fluid perfusion. Our study demonstrates that neurons serve as master organizers for brain clearance. This fundamental principle introduces a new theoretical framework for the functioning of macroscopic brain waves.<p /> <p>Language: en</p>",
language="en",
issn="0028-0836",
doi="10.1038/s41586-024-07108-6",
url="http://dx.doi.org/10.1038/s41586-024-07108-6"
}