@article{ref1,
title="Chlorpropamide toxicity with survival despite 27-day hypoglycemia",
journal="Journal of toxicology - clinical toxicology",
year="1999",
author="Ciechanowski, K. and Borowiak, K. S. and Potocka, B. A. and Nowacka, M. and Dutkiewicz, G.",
volume="37",
number="7",
pages="869-871",
abstract="In the past 5 years at our institution, 12 cases involving the ingestion of chlorpropamide 3-15 g were fatal. We report a 23-year-old woman with an estimated ingestion of chlorpropamide 5-10 g. Initial cardiovascular collapse, attributed to the blockade of potassium channel transport, responded to intensive support including 3 days of cardiac pacing. Urinary excretion of chlorpropamide and hypoglycemia persisted until day 27. The toxic mechanisms and high risk of chlorpropamide are summarized. A fatal therapeutic dose ratio as low as 4:1 has made this antidiabetic agent obsolete.<p /> <p>Language: en</p>",
language="en",
issn="0731-3810",
doi="10.1081/clt-100102468",
url="http://dx.doi.org/10.1081/clt-100102468"
}